Sanquin CLB's department of Autoimmune Diseases has a longstanding record in researching various aspects of rheumatic diseases, both in cellular immunology (e.g. cytokines) and in serology (e.g. autoantibodies). Through this research, know-how of serological tests as well as of immunoregulatory mechanisms is abundantly present. The lasting collaboration with major Rheumatology clinics has facilitated numerous (clinical) studies of immunological concepts in rheumatic patients.
New therapeutic principles in rheumatic diseases specifically aim at intervention in the immune regulation of these diseases (e.g. anti-TNFa and soluble TNFa-receptors). Measurements of the cytokine/interleukine repertoire is an essential aspect in the development and application of such new therapeutical interventions.
Sanquin CLB's department has an extensive portfolio of advanced tests available to this field. In addition, scientific specialists are avail-able for the design and implementation of
tailor-made test-systems for specific clinical trial objectives.
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Sanquin CLB's diagnostic tests for Rheumatology: |  |
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Rheumatoid serology
Anti-perinuclear factor
Anti-citrullinated peptide antibody
Rheumatoid factors
Anti-streptolysin titer
Anti-Dnase B
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LE-serology
Anti-nuclear antibodies (ANA)
Anti-dsDNA antibodies
Anti-RNP
Anti-Sm
Anti-SS-A
Anti-SS-B
Anti-Jo1
Anti-Scl-70
Anti-Centromer
Anti-Histones
Anti-Cardiolipin |
Various cytokines
IL-1b; IL-2; IL-4; IL-6; IL-8; IL-10; IL-12; IL-13; TNFa; IFNg; GM-CSF; TPO |
Soluble membrane markers
sCD16(neutrophil)
sCD25 (T cell)
sCD27 (T and B cell)
sCD46 (all hemapoietic cells except erythrocytes)
sCD55 (all hemapoietic cells)
sCD95 |
Acute phase proteins
CRP
sPLA2
complexes of CRP with C3 and C4
MBL (protein level, genotyping) |