As leading blood-supply organization, Sanquin is engaged in the diagnosis of various blood-borne viruses on a routine basis. Through this task, and the cooperation with leading suppliers of sophisticated analytical systems, Sanquin has advanced to a unique position in this field.
The intense cooperation with major clinics in the Amsterdam-region has resulted in a profound knowledge base for such viruses as HIV, HBV, HCV, HTLV and others. Sanquin offers state-of-the-art tests in immunology and viral serology, plus very advanced diagnostics in molecular virology.
In the field of HIV, Sanquin offers various viral load tests plus restrictive prescription tests such as genotyping and phenotyping on a routine basis. The following tests summarize the available routine repertoire; specific tests can be developed on demand.
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Sanquin diagnostic virology and immunology tests
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Virology
HIV-1 phenotypic resistance assay
HIV-1 genotypic resistance assay
Quantification of HIV-1 DNA
Quantification of residual replication-competent HIV-1 from resting CD4+T cells ("latent eservoir")
HIV-1 biological phenotyping
Quantification of HIV-1 RNA in serum and plasma
Quantification of HCV RNA
Genotyping HCV RNA
Quantification of HBV DNA
Qualification of HBV, HIV-1, HTLV DNA |
Immunology
Immunophenotyping of T and B lymphocytes using CD panel
Activation status of CD4+ and CD8+ lymphocytes
Maturation status of CD4+ and CD8+ lymphocytes (naive/memory)
Measurement of thymic function
Measurement of T-cell turnover and cell-division rates
T-cell function using a whole blood culture system
Quantification of virus (HIV/EBV/CMV/HCV/HBV)-specific CD8+ T cells
Quantification of cytokine (IFN-g)-producing virus specific CD4+ and CD8+ T cells by ELISPOT (1) or by intracellular staining (2) CCR5 genotype |
Viral serology
Antibody screening (HIV-1/2; HTLV-I/II; HCV; HBV)
Confirmation assays (HIV-1/2; HTLV-I/II)
Antigen screening (HBV; HIV-1 p24)
Neutralization assays |
Efficacy testing of anti-virals |