Sanquin Home Sanquin Home Sanquin
Home ● Contact ● Sanquin ● News ● Jobs ● Sitemap ●
Jos (J) van Rijssel

Department: Molecular Cell Biology

E-mail: j.vanrijssel@sanquin.nl

Training: Cell biology/Biochemistry

Research interests: During inflammation leukocytes form the circulation transmigrate across the endothelium towards the site of injury. Leukocytes adhere to the endothelium through interactions with the endothelial adhesion receptors ICAM-1 and VCAM-1. Upon binding and clustering of ICAM-1 and VCAM-1, various Rho-like GTPases become activated which induce endothelial shape changes to allow passage of the transmigrating leukocytes. Our current focus is identifying the signalling pathways downstream of ICAM-1 and VCAM-1 that lead to the activation of these small GTPases.

Technology: Pulldown and immunoprecipitation assays for analysis of protein-protein interactions; Confocal microscopy and live cell imaging; Transwell migration; Cell culturing; Western blotting.

Resume:

2004/2005:
Internship at the Department of medical biochemistry, Academic Medical Centre (AMC), Amsterdam

2006:
Internship at the Department of Molecular Cell Biology, Sanquin Research, Amsterdam

2006:
MSc in Medical biology at the University of Amsterdam

2007-present:
PhD student at the department of Molecular Cell Biology, Sanquin research, Amsterdam

Sanquin publications

Other publications
  • Dekker N, van Rijssel J, Distel B, Hochstenbach F. Role of the alpha-glucanase Agn2p in ascus-wall endolysis following sporulation in fission yeast. Yeast 2007; 24(4):279-88.




« back