Department: Molecular Cell Biology
E-mail: m.fernandez@sanquin.nl
Training: Cell Biology and Biochemistry
Research Interests:
Regulation of endothelial integrity by the actin and microtubule cytoskeletons
Cytoskeletal dynamics play a crucial role in the stability of endothelial intercellular contacts. The current focus is on the co-operation between the actin and microtubule cytoskeleton dynamics in the regulation of cell-cell adhesion. In addition, the involvement of small GTPases of the Rho and Rab families and their targets in the regulation of endothelial cell-cell adhesion is being currently explored.
Technology: Confocal microscopy; Microinjection; Protein Biochemistry techniques.
Resume:
1994: |
PhD Biochemistry (University of Barcelona, Spain) |
1995-2002: |
Post-doc training at the Netherlands Cancer Institute, Amsterdam (group Jacques Neefjes) |
2002-present: |
Senior post-doctoral fellow at the Molecular Cell Biology Department, Sanquin Research, Amsterdam |
Sanquin publications
Other publications
Jordens I, Fernandez-Borja M, Marsman M, Dusseljee S, Janssen L, Calafat J, Janssen H, Wubbolts R, Neefjes J. The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors. Curr Biol. 2001; 11:1680-5.
Wubbolts R, Fernandez-Borja M, Jordens I, Reits E, Dusseljee S, Echeverri C, Vallee RB, Neefjes J. Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II-containing compartments. J Cell Sci. 1999; 112:785-95.
Fernandez-Borja M, Wubbolts R, Calafat J, Janssen H, Divecha N, Dusseljee S, Neefjes J. Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity. Curr Biol. 1999; 9:55-8.
Martinho RG, Castel S, Urena J, Fernandez-Borja M, Makiya R, Olivecrona G, Reina M, Alonso A, Vilaro S. Ligand binding to heparan sulfate proteoglycans induces their aggregation and distribution along actin cytoskeleton. Mol Biol Cell. 1996; 7:1771-88.
Wubbolts R, Fernandez-Borja M, Oomen L, Verwoerd D, Janssen H, Calafat J, Tulp A, Dusseljee S, Neefjes J. Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface. J Cell Biol. 1996; 135:611-22.
Fernandez-Borja M, Verwoerd D, Sanderson F, Aerts H, Trowsdale J, Tulp A, Neefjes J. HLA-DM and MHC class II molecules co-distribute with peptidase-containing lysosomal subcompartments. Int Immunol. 1996; 8:625-40.
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